Cyclical caspofungin for chronic pulmonary aspergillosis in sarcoidosis.
نویسندگان
چکیده
In sarcoidosis, chronic pulmonary aspergillosis (CPA) may be associated with significant morbidity, and treatment failure rates are often high, even with newer triazole antifungal agents. We report a treatment regimen of cyclical caspofungin infusions in 10 patients with sarcoidosis and worsening CPA despite oral triazoles.
منابع مشابه
Sarcoidosis and aspergillosis: a tough combination.
It should have been a wake-up call. Thirty years ago, TOMLINSON and SAHN [1] found that seven out of 12 (58%) patients with aspergillosis complicating sarcoidosis died over a 2 year period. Three years earlier, WOLLSCHLAGER and KHAN [2] had found evidence of aspergillosis in 12% of 100 consecutive sarcoidosis referrals, and aspergillomas were found in 53% of the 19 patients with fibrocystic asp...
متن کاملGlobal burden of chronic pulmonary aspergillosis complicating sarcoidosis.
Chronic pulmonary aspergillosis (CPA) may complicate pulmonary sarcoidosis. We re-estimated the global burden of sarcoidosis and the burden of CPA complicating sarcoidosis. We searched the literature and reference lists of retrieved papers to identify all published sarcoidosis incidence and prevalence data. We estimated the frequency of CPA from 11 papers relating to >3,000 patients with sarcoi...
متن کاملEfficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy.
BACKGROUND Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised patients. Echinocandins are novel antifungal molecules with in vitro and in vivo activity against Aspergillus species. METHODS We investigated the efficacy and safety of caspofungin in the treatment of IA. Ninety patients with IA who were refractory to or intolerant of amphotericin ...
متن کاملEvidence Supporting a Role for Mammalian Chitinases in Efficacy of Caspofungin against Experimental Aspergillosis in Immunocompromised Rats
OBJECTIVES Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy. Therefore the question arises how this in vivo activity is reached. Caspofungin is known to increase the amount of chitin in the fungal cell wall. Mammals produce...
متن کاملRapid improvement of osseous sarcoidosis after the treatment of pulmonary aspergillosis by itraconazole.
Osseous sarcoidosis is relatively uncommon, and treatment with corticosteroids is not always effective. Moreover, patients with an advanced stage of pulmonary sarcoidosis are sometimes infected with aspergillus in the cavities of the pulmonary lesions, and long-term use of corticosteroids should be prohibited to prevent the development of fatal invasive pulmonary aspergillosis. Here, we describ...
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ورودعنوان ژورنال:
- Thorax
دوره 69 3 شماره
صفحات -
تاریخ انتشار 2014